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C5AR1 antibody (FITC)
C5AR1
Reactivity: Human
FACS
Host: Mouse
Monoclonal
S5-1
FITC
Product Details anti-C5AR1 Antibody (FITC)
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Target
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C5AR1
(Complement Component 5a Receptor 1 (C5AR1))
Reactivity
All reactivities for C5AR1 antibodies
Human
Host
All hosts for C5AR1 antibodies
Mouse
Clonality
All clonalities for C5AR1 antibodies
Monoclonal
Conjugate
All conjugates for C5AR1 antibodies
This C5AR1 antibody is conjugated to FITC
Application
All applications for C5AR1 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone
S5-1
Isotype
IgG2a kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for C5AR1
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Target
C5AR1
(Complement Component 5a Receptor 1 (C5AR1))
Alternative Name
CD88 (C5AR1 Products )
Synonyms
C5A antibody, C5AR antibody, C5R1 antibody, CD88 antibody, C5aR antibody, C5r1 antibody, Cd88 antibody, D7Msu1 antibody, GPR77 antibody, complement C5a receptor 1 antibody, complement component 5a receptor 1 antibody, C5AR1 antibody, C5ar1 antibody, c5ar1 antibody
Background
CD88 is a single chain protein with seven membrane-spanning regions and has a MW of 43 kD. CD88 is expressed by monocytes, neutrophils and eosinophils. Also, there have been reports of CD88 expression in non-immune cells such as glial cells, cerebellar granule cells, cardiomyocytes and vascular endothelial cells. CD88 is coupled to heterotrimeric G proteins such as Gi, and after C5a binding, the signal transduced by CD88 results in the activation of PLCβ, PI-3 kinase, and PLA2, among other molecules, resulting in chemotaxis, granule enzyme release and superoxide anion production.
Pathways
Complement System
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