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CD8 alpha antibody (FITC)
CD8A
Reactivity: Human
ICFC
Host: Mouse
Monoclonal
HIT8a
FITC
Product Details anti-CD8 alpha Antibody (FITC)
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Target
See all CD8 alpha (CD8A) Antibodies
CD8 alpha (CD8A)
(CD8a Molecule (CD8A))
Reactivity
All reactivities for CD8 alpha antibodies
Human
Host
All hosts for CD8 alpha antibodies
Mouse
Clonality
All clonalities for CD8 alpha antibodies
Monoclonal
Conjugate
All conjugates for CD8 alpha antibodies
This CD8 alpha antibody is conjugated to FITC
Application
All applications for CD8 alpha antibodies
Intracellular Flow Cytometry (ICFC)
Cross-Reactivity
Chimpanzee, Marmoset
Purification
The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.
Clone
HIT8a
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for CD8 alpha
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Target
CD8 alpha (CD8A)
(CD8a Molecule (CD8A))
Alternative Name
CD8a (CD8A Products )
Synonyms
cd8 antibody, LOC100136450 antibody, BB154331 antibody, Ly-2 antibody, Ly-35 antibody, Ly-B antibody, Lyt-2 antibody, zgc:136643 antibody, CD8 antibody, Leu2 antibody, MAL antibody, p32 antibody, RHACD8-4 antibody, CD8a molecule antibody, uncharacterized LOC100125537 antibody, CD8 alpha antibody, CD8 antigen, alpha chain antibody, T-cell surface glycoprotein CD8 alpha chain antibody, Cd8a antibody, LOC100125537 antibody, LOC100136450 antibody, CD8A antibody, cd8a antibody, LOC100126556 antibody
Background
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Pathways
TCR Signaling
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