The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
CLEC4A antibody, CLECSF6 antibody, DCIR antibody, DDB27 antibody, LLIR antibody, Clecsf6 antibody, Dcir1 antibody, Clec4a antibody, zinc finger protein 705A antibody, C-type lectin domain family 4 member A antibody, C-type lectin domain family 4, member A antibody, C-type lectin domain family 4, member a2 antibody, ZNF705A antibody, CLEC4A antibody, Clec4a antibody, Clec4a2 antibody
Background
CD367 (CLEC4A), also known as lectin-like immunoreceptor (LLIR) and dendritic cell immunoreceptor (DCIR), is a type II transmembrane protein belonging to C-type lectin domain family, and was previously designated as CLECSF6. It contains one carbohydrate recognition domain in its C-terminal extracellular domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. CLEC4A is mainly expressed on monocytes, macrophages, dendritic cells, neutrophils, and B cells. It is also found on the surface of CD4+ T cells in rheumatoid arthritis (RA) patients. CLEC4A has been reported to function as a receptor for HIV, cross-present and cross-prime human CD8+ T cells. It might also function as a negative player by recruiting the SHP-1 or/and SHP-2 phosphotase through its immunoreceptor tyrosine-based inhibitory motif (ITIM).