IL16 antibody (Interleukin 16) (AA 615-630) (PE)

Details for Product anti-IL16 Antibody No. ABIN2662757, Supplier: Log in to see
Antigen
  • IL16
  • LCF
  • NIL16
  • PRIL16
  • prIL-16
  • mKIAA4048
  • IL-16
  • interleukin 16
  • interleukin 16 (lymphocyte chemoattractant factor)
  • IL16
  • Il16
Epitope
AA 615-630
28
18
13
8
8
7
7
7
5
5
3
3
3
2
2
1
1
1
1
1
Reactivity
Human
197
40
29
3
2
2
1
1
1
Host
Mouse
121
89
4
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This IL16 antibody is conjugated to PE
11
5
3
3
3
3
3
3
3
3
2
2
1
1
1
Application
Flow Cytometry (FACS)
130
105
42
35
19
19
17
16
13
7
6
5
4
2
2
2
2
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen AA 615-630 (RRKSLQSKETTAAGDS) of IL-16
Clone 14-1
Isotype IgG2a
Cross-Reactivity Mouse (Murine)
Purification The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Alternative Name IL-16 (IL16 Antibody Abstract)
Background Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+ T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replication in vitro by repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.
Research Area Signaling, Cytokines, Immunology, Virology, Inflammation, Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (ABIN2662757) anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE)
Flow Cytometry (FACS) image for anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (ABIN2662757) anti-Interleukin 16 (IL16) (AA 615-630) antibody (PE) (Image 2)
Background publications Bellon, Baydoun, Yao, Nicot: "HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes." in: Blood, Vol. 115, Issue 12, pp. 2441-8, 2010 (PubMed).

Cruikshank, Little: "lnterleukin-16: the ins and outs of regulating T-cell activation." in: Critical reviews in immunology, Vol. 28, Issue 6, pp. 467-83, 2009 (PubMed).

Rofani, Luchetti, Testa, Lasorella, Isacchi, Bottazzo, Berardi: "IL-16 can synergize with early acting cytokines to expand ex vivo CD34+ isolated from cord blood." in: Stem cells and development, Vol. 18, Issue 4, pp. 671-82, 2009 (PubMed).

Gu, Lewis, Deere, Groome, Wang: "Elevated maternal IL-16 levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 6, pp. 4418-22, 2008 (PubMed).

McFadden, Morgan, Rahangdale, Green, Yamasaki, Center, Cruikshank: "Preferential migration of T regulatory cells induced by IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 10, pp. 6439-45, 2007 (PubMed).

Qi, Wang, Mandadi, Tanaka, Roufogalis, Madigan, Lai, Yan, Chong, Stevens, Krilis: "Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor." in: Blood, Vol. 107, Issue 1, pp. 135-42, 2005 (PubMed).

Ren, Zhan, Martens, Lee, Center, Hanson, Kornfeld: "Pro-IL-16 regulation in activated murine CD4+ lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 5, pp. 2738-45, 2005 (PubMed).

Stoitzner, Ratzinger, Koch, Janke, Schöller, Kaser, Tilg, Cruikshank, Fritsch, Romani: "Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way." in: The Journal of investigative dermatology, Vol. 116, Issue 5, pp. 641-9, 2001 (PubMed).

Chupp, Wright, Wu, Vallen-Mashikian, Cruikshank, Center, Kornfeld, Berman: "Tissue and T cell distribution of precursor and mature IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 6, pp. 3114-9, 1998 (PubMed).

Keane, Nicoll, Kim, Wu, Cruikshank, Brazer, Natke, Zhang, Center, Kornfeld: "Conservation of structure and function between human and murine IL-16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 12, pp. 5945-54, 1998 (PubMed).

Cruikshank, Center, Nisar, Wu, Natke, Theodore, Kornfeld: "Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 5109-13, 1994 (PubMed).

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