CLEC7A antibody (PE)

Catalog No. ABIN2663426

Product Details anti-CLEC7A Antibody (PE)

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CLEC7A antibody is conjugated to PE

Application: Intracellular Flow Cytometry (ICFC)

Purification: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: RH1

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CLEC7A

Target: CLEC7A (C-Type Lectin Domain Family 7, Member A (CLEC7A))

Alternative Name: CD369 (CLEC7A Products)

Synonyms: CLEC7A antibody, BGR antibody, Clecsf12 antibody, beta-GR antibody, CANDF4 antibody, CLECSF12 antibody, DECTIN1 antibody, Clec7b antibody, RGD1565140 antibody, C-type lectin domain containing 7A antibody, C-type lectin domain family 7, member a antibody, CLEC7A antibody, Clec7a antibody

Background: CD369 (Dectin-1), also known as CLEC7A, is a 43 kD type II transmembrane protein. The extracellular portion of Dectin-1 contains one C-type lectin domain, and its cytoplasmic tail has one immunoreceptor tyrosine-based activation motif (ITAM). Dectin-1 binds β-1,3-linked and β-1,6-glucans (abundant in the cell wall of fungi and yeast), mediates phagocytosis, and induces cytokine production and oxidative burst. It is also involved in TLR2-mediated NF-kB activation. Dectin-1 is expressed by macrophages, neutrophils, dendritic, and Langerhans cells.

Pathways: Activation of Innate immune Response