DcR2 (TNFRSF10D)
(Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
Reactivity
Mouse
Host
Armenian Hamster
Clonality
Monoclonal
Conjugate
This DcR2 antibody is conjugated to PE
Application
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Mouse Decoy Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Receptor 2 (mDcTRAIL-R2) is highly homologous to mDcTRAIL R1. It is a GPI-anchored mouse TNF receptor super-family member that lacks a cytoplasmic death domain. It is expressed on many cell types, including some tumor cells. It was reported that overexpression of mDcTRAIL-R2 did not induce caspase activation that is characteristic of death receptor signaling. mDcTRAIL-R2 appears to have a negative effect against TRAIL receptors because it lacks an intracellular death domain, and produces a competitive blockage of TRAIL-mediated apoptosis. The role of the DcTRAIL-R2 in apoptosis has not yet been completely clarified.