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Thrombomodulin antibody
THBD
Reactivity: Human
FACS
Host: Mouse
Monoclonal
M80
unconjugated
Product Details anti-Thrombomodulin Antibody
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Target
See all Thrombomodulin (THBD) Antibodies
Thrombomodulin (THBD)
Reactivity
All reactivities for Thrombomodulin antibodies
Human
Host
All hosts for Thrombomodulin antibodies
Mouse
Clonality
All clonalities for Thrombomodulin antibodies
Monoclonal
Conjugate
All conjugates for Thrombomodulin antibodies
This Thrombomodulin antibody is un-conjugated
Application
All applications for Thrombomodulin antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
M80
Isotype
IgG1 kappa
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for Thrombomodulin
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Target
Thrombomodulin (THBD)
Alternative Name
CD141 (THBD Products )
Synonyms
AHUS6 antibody, BDCA3 antibody, CD141 antibody, THPH12 antibody, THRM antibody, TM antibody, AI385582 antibody, THBD antibody, HAST antibody, HAST3 antibody, M-PST antibody, ST1A3/ST1A4 antibody, ST1A5 antibody, STM antibody, TL-PST antibody, thrombomodulin antibody, sulfotransferase family 1A member 3 antibody, THBD antibody, Thbd antibody, SULT1A3 antibody
Background
CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development.
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