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Sialoadhesin/CD169 antibody
SIGLEC1
Reactivity: Human
FACS
Host: Mouse
Monoclonal
7-239
unconjugated
Product Details anti-Sialoadhesin/CD169 Antibody
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Target
See all Sialoadhesin/CD169 (SIGLEC1) Antibodies
Sialoadhesin/CD169 (SIGLEC1)
(Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))
Reactivity
All reactivities for Sialoadhesin/CD169 antibodies
Human
Host
All hosts for Sialoadhesin/CD169 antibodies
Mouse
Clonality
All clonalities for Sialoadhesin/CD169 antibodies
Monoclonal
Conjugate
All conjugates for Sialoadhesin/CD169 antibodies
This Sialoadhesin/CD169 antibody is un-conjugated
Application
All applications for Sialoadhesin/CD169 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
7-239
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for Sialoadhesin/CD169
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Target
Sialoadhesin/CD169 (SIGLEC1)
(Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))
Alternative Name
CD169 (SIGLEC1 Products )
Synonyms
Cd169 antibody, Siglec-1 antibody, Sn antibody, CD169 antibody, SIGLEC-1 antibody, SN antibody, dJ1009E24.1 antibody, SA antibody, SIGLEC1 antibody, p210 antibody, pSn antibody, sialic acid binding Ig like lectin 1 antibody, sialic acid binding Ig-like lectin 1, sialoadhesin antibody, SIGLEC1 antibody, Siglec1 antibody
Background
CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a 210 kD type I single membrane-spanning glycoprotein. It is the largest member of the Siglec family, consisting of 1709 amino acids and belonging to the immunoglobulin superfamily. CD169 is expressed by macrophages and dendritic cells. By its affinity to α2,3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B and T cells. Several CD169 counter receptors, such as CD227 on human breast cancer cells, CD43 on T cells and CD206 on macrophages, have been reported.
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