Sialoadhesin/CD169 antibody

Catalog No. ABIN7249626

Product Details anti-Sialoadhesin/CD169 Antibody

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sialoadhesin/CD169 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse CD169

Isotype: IgG

Application Details

Application Notes: IHC 1:200-1:800

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.4 mg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Sialoadhesin/CD169

Target: Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))

Alternative Name: CD169 (SIGLEC1 Products)

Synonyms: Cd169 antibody, Siglec-1 antibody, Sn antibody, CD169 antibody, SIGLEC-1 antibody, SN antibody, dJ1009E24.1 antibody, SA antibody, SIGLEC1 antibody, p210 antibody, pSn antibody, sialic acid binding Ig like lectin 1 antibody, sialic acid binding Ig-like lectin 1, sialoadhesin antibody, SIGLEC1 antibody, Siglec1 antibody

Background: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound, however, the full-length nature of this variant has not been determined.SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Proliferative Glomerulonephritis and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.

UniProt: Q9BZZ2, Q62230