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CD35 antibody
CR1
Reactivity: Human
FACS
Host: Mouse
Monoclonal
E11
unconjugated
Product Details anti-CD35 Antibody
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Target
See all CD35 (CR1) Antibodies
CD35 (CR1)
(Complement Component Receptor 1 (CD35) (CR1))
Reactivity
All reactivities for CD35 antibodies
Human
Host
All hosts for CD35 antibodies
Mouse
Clonality
All clonalities for CD35 antibodies
Monoclonal
Conjugate
All conjugates for CD35 antibodies
This CD35 antibody is un-conjugated
Application
All applications for CD35 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography.
Clone
E11
Isotype
IgG1 kappa
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C.
Target Details for CD35
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Target
CD35 (CR1)
(Complement Component Receptor 1 (CD35) (CR1))
Alternative Name
CD35 (CR1 Products )
Synonyms
C3BR antibody, C4BR antibody, CD35 antibody, KN antibody, C3DR antibody, CD21 antibody, Cr-1 antibody, Cr-2 antibody, Cr1 antibody, CR1-L antibody, CR2 antibody, CR1 antibody, complement C3b/C4b receptor 1 (Knops blood group) antibody, complement receptor 2 antibody, complement component (3d/Epstein Barr virus) receptor 2 antibody, complement receptor type 1 antibody, CR1 antibody, Cr2 antibody, CR2 antibody, LOC718120 antibody
Background
CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.
Pathways
Complement System , Regulation of Leukocyte Mediated Immunity , Positive Regulation of Endopeptidase Activity
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