CD79b antibody

Catalog No. ABIN2664824

Product Details anti-CD79b Antibody

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Reactivity: Mouse

Host: Armenian Hamster

Clonality: Monoclonal

Conjugate: This CD79b antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: HM79-12

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C.

Target Details for CD79b

Target: CD79b (CD79B) (CD79b Molecule, Immunoglobulin-Associated beta (CD79B))

Alternative Name: CD79b (CD79B Products)

Synonyms: B29 antibody, Ig-beta antibody, Igb antibody, Igbeta antibody, AGM6 antibody, IGB antibody, CD79B antigen antibody, CD79b molecule antibody, Cd79b antibody, CD79B antibody

Background: Mouse CD79b (Igβ chain) is a 35-40kD transmembrane protein that forms a heterodimer with CD79a (30-35 kD, Ig α chain).The CD79b and CD79a hererodimers are associated with surface IgM to form the B-cell receptor (BCR) that is necessary for signal transduction via the BCR in mature B cells.CD79b participates signal transduction involved in the development of B cells as well. It was reported that association between CD79b/CD79a with IgM is essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion.Igβ knockout mice had a complete block in B cell development at the immature CD43+B220+ stage. The HM79b-12 react with an extracellular epitope of CD79b or Ig β.

Pathways: BCR Signaling