TIGIT antibody
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- Target See all TIGIT Antibodies
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
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Reactivity
- Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TIGIT antibody is un-conjugated
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Application
- Intracellular Flow Cytometry (ICFC)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 1G9
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product TIGIT Primary Antibody
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anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 21-234) antibody
TIGIT Reactivity: Human WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT Reactivity: Human WB, ELISA, IHC, ICC, FACS, Neut Host: Mouse Monoclonal 4C5B9 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT Reactivity: Human ELISA, IHC, FACS, Coat, StM Host: Mouse Monoclonal TIGIT-3017 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-246) antibodyTIGIT Reactivity: Mouse WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT Reactivity: Human ELISA, IHC, Coat, StM Host: Mouse Monoclonal TIGIT-3106 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 28-227) antibodyTIGIT Reactivity: Rat WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT Reactivity: Mouse ELISA, FACS, BP Host: Rabbit Chimeric 1B4 unconjugated Recombinant Antibody
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) antibodyTIGIT Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 12-142) antibodyTIGIT Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB55818 unconjugated
anti-T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) antibodyTIGIT Reactivity: Mouse FACS, Agon Host: Rabbit Chimeric 4D4 unconjugated Recombinant Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- Alternative Name
- TIGIT (TIGIT Products)
- Synonyms
- VSIG9 antibody, VSTM3 antibody, WUCAM antibody, ENSMUSG00000071552 antibody, Vstm3 antibody, RGD1563191 antibody, T-cell immunoreceptor with Ig and ITIM domains antibody, T cell immunoreceptor with Ig and ITIM domains antibody, TIGIT antibody, Tigit antibody
- Background
- T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as V-set and transmembrane domain-containing protein 3 (Vstm3), is a 26 kD, type I transmembrane protein and member of the CD28 family. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. Its ligands are PVR, PVRL2, PVRL3, CD155, and CD112. TIGIT is a negative regulator of NK and T cell activation. Engagement of TIGIT by dendritic cells results in their differentiation into a tolerogenic phenotype, with an increased secretion of IL-10 and a diminished production of IL-12. Mice deficient for TIGIT are more susceptible to autoimmune disease.
- Pathways
- Cancer Immune Checkpoints
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