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PTCRA antibody

PTCRA Reactivity: Mouse IP, FACS Host: Mouse Monoclonal 2F5 unconjugated
Catalog No. ABIN2689882
  • Target See all PTCRA Antibodies
    PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))
    Reactivity
    Mouse
    Host
    • 15
    Mouse
    Clonality
    • 15
    Monoclonal
    Conjugate
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    This PTCRA antibody is un-conjugated
    Application
    Immunoprecipitation (IP), Flow Cytometry (FACS)
    Brand
    BD Pharmingen™
    Characteristics
    At very early stages in the intrathymic differentiation of T lymphocytes which will bear αβ T Cell Receptors (TCR), the TCR β chain forms a heterodimer with the pre-TCR α chain (pTα) to form the pre-TCR. This pre-TCR associates with the signal-transducing CD3 complex and controls the survival and proliferation of CD4- CD8- (DN) thymocytes, plays a role in allelic exclusion of the TCR β chain, directly or indirectly regulates TCR δ chain expression, and is eventually replaced by the TCR α chain as thymocytes mature. The 2F5 antibody reacts with the PTα on the surface of CD44- CD25-/lo DN thymocytes.

    BD Pharmingen™ Purified Mouse Anti-Mouse Pre-T Cell Receptor α Chain - Purified - Clone 2F5 - Isotype Mouse IgG1, κ - Reactivity Ms - 0.1 mg
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Recombinant extracellular (Ig-like) domain of pTalpha
    Clone
    2F5
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product PTCRA Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store undiluted at 4°C.
  • Aifantis, Feinberg, Fehling, Di Santo, von Boehmer: "Early T cell receptor beta gene expression is regulated by the pre-T cell receptor-CD3 complex." in: The Journal of experimental medicine, Vol. 190, Issue 1, pp. 141-4, (1999) (PubMed).

    Aifantis, Pivniouk, Gärtner, Feinberg, Swat, Alt, von Boehmer, Geha: "Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein." in: The Journal of experimental medicine, Vol. 190, Issue 8, pp. 1093-102, (1999) (PubMed).

    Wiest, Berger, Carleton: "Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?" in: Seminars in immunology, Vol. 11, Issue 4, pp. 251-62, (1999) (PubMed).

    von Boehmer, Aifantis, Feinberg, Lechner, Saint-Ruf, Walter, Buer, Azogui: "Pleiotropic changes controlled by the pre-T-cell receptor." in: Current opinion in immunology, Vol. 11, Issue 2, pp. 135-42, (1999) (PubMed).

    Aifantis, Azogui, Feinberg, Saint-Ruf, Buer, von Boehmer: "On the role of the pre-T cell receptor in alphabeta versus gammadelta T lineage commitment." in: Immunity, Vol. 9, Issue 5, pp. 649-55, (1998) (PubMed).

    von Boehmer, Fehling: "Structure and function of the pre-T cell receptor." in: Annual review of immunology, Vol. 15, pp. 433-52, (1997) (PubMed).

  • Target
    PTCRA (Pre T-Cell Antigen Receptor alpha (PTCRA))
    Alternative Name
    Pre-T Cell Receptor alpha Chain (PTCRA Products)
    Synonyms
    gp33 antibody, pT-alpha antibody, pT-alpha-TCR antibody, pT[a] antibody, pTa antibody, pTalpha antibody, PT-ALPHA antibody, PTA antibody, pre T cell antigen receptor alpha antibody, pre T-cell antigen receptor alpha antibody, Ptcra antibody, PTCRA antibody
    Background
    Synonyms: pTα
    Pathways
    Cancer Immune Checkpoints
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