CYP2A6 antibody (C-Term)
-
- Target See all CYP2A6 Antibodies
- CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
-
Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Horse, Cow, Dog, Guinea Pig, Rabbit, Sheep
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This CYP2A6 antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV YPMLGSVLRD
- Predicted Reactivity
- Cow: 92%, Dog: 86%, Guinea Pig: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 85%, Rat: 92%, Sheep: 92%
- Characteristics
- This is a rabbit polyclonal antibody against CYP2A6. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human CYP2A6
- Top Product
- Discover our top product CYP2A6 Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 494 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
- Alternative Name
- CYP2A6 (CYP2A6 Products)
- Synonyms
- CPA6 antibody, CYP2A antibody, CYP2A3 antibody, CYPIIA6 antibody, P450C2A antibody, P450PB antibody, cyp2a6 antibody, cytochrome P450 family 2 subfamily A member 6 antibody, cytochrome P450 2A6 antibody, cytochrome P450 family 2 subfamily A member 6 L homeolog antibody, CYP2A6 antibody, cyp2a6.L antibody
- Background
-
CYP2A6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3, however, it has been renamed CYP2A6.
Alias Symbols: CPA6, CYP2A, CYP2A3, P450C2A, P450PB, CYPIIA6
Protein Interaction Partner: POR, CYB5A,
Protein Size: 494 - Molecular Weight
- 56 kDa
- Gene ID
- 1548
- NCBI Accession
- NM_000762, NP_000753
- UniProt
- P11509
-