CHRNB2 antibody (Middle Region)
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- Target See all CHRNB2 Antibodies
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Pig, Cow, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CHRNB2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- CKIEVKHFPF DQQNCTMKFR SWTYDRTEID LVLKSEVASL DDFTPSGEWD
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2
- Top Product
- Discover our top product CHRNB2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 502 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
- Alternative Name
- CHRNB2 (CHRNB2 Products)
- Synonyms
- EFNL3 antibody, nAChRB2 antibody, NACHRB2 antibody, Acrb-2 antibody, Acrb2 antibody, C030030P04Rik antibody, [b]2-nAchR antibody, cholinergic receptor nicotinic beta 2 subunit antibody, cholinergic receptor nicotinic beta 2 subunit S homeolog antibody, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) antibody, CHRNB2 antibody, chrnb2.S antibody, Chrnb2 antibody
- Background
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CRELD2, CHRNA4, CHRNA2,
Protein Size: 502 - Molecular Weight
- 57 kDa
- Gene ID
- 1141
- NCBI Accession
- NM_000748, NP_000739
- UniProt
- P17787
- Pathways
- Sensory Perception of Sound, Feeding Behaviour
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