SCN5A antibody (C-Term)
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- Target See all SCN5A Antibodies
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Guinea Pig, Horse, Zebrafish (Danio rerio), Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SCN5A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- FTKRVLGESG EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAM
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SCN5A. It was validated on Western Blot and immunohistochemistry.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human SCN5A
- Top Product
- Discover our top product SCN5A Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 2015 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." in: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).
: "Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells." in: American journal of physiology. Heart and circulatory physiology, Vol. 302, Issue 1, pp. H270-7, (2011) (PubMed).
: "The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice." in: Cardiovascular research, Vol. 87, Issue 1, pp. 73-82, (2010) (PubMed).
: "Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion." in: Cancer research, Vol. 70, Issue 17, pp. 6957-67, (2010) (PubMed).
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Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." in: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).
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- Target
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
- Alternative Name
- SCN5A (SCN5A Products)
- Synonyms
- Nav1.5 antibody, Nav1.5c antibody, SkM1 antibody, SkM2 antibody, mH1 antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, SSS1 antibody, VF1 antibody, SCAL antibody, sodium voltage-gated channel alpha subunit 5 antibody, sodium channel, voltage-gated, type V, alpha antibody, SCN5A antibody, Scn5a antibody
- Background
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SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram.The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform.
Alias Symbols: CDCD2, CMD1E, CMPD2, HB1, HB2, HH1, IVF, LQT3, Nav1.5, SSS1, VF1, HBBD, ICCD, PFHB1
Protein Interaction Partner: CALM1, CAV3, ALB, Nedd4, WWP2, UBC, SNTG2, NEDD4L, DLG2, INADL, DLG4, RGS3, SNTA1, DLG1, RGS2, SCN5A, SNTB2, SNTB1, DLG3, CBL,
Protein Size: 2015 - Molecular Weight
- 222 kDa
- Gene ID
- 6331
- NCBI Accession
- NM_000335, NP_000326
- UniProt
- Q8IZC9
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