Carbonic Anhydrase IV (CA4) (Middle Region) antibody

Details for Product No. ABIN2776799, Supplier: Log in to see
Antigen
  • caiv
  • car4
  • rp17
  • CA4
  • ca4
  • AW456718
  • Ca4
  • CAIV
  • Car4
  • RP17
  • carbonic anhydrase IV
  • carbonic anhydrase 4
  • ca4
  • CA4
  • Car4
  • Ca4
Epitope
Middle Region
10
8
5
4
3
3
3
2
1
1
1
1
1
1
Reactivity
Human
49
21
7
1
1
1
1
Host
Rabbit
47
13
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
Application
Western Blotting (WB)
54
28
15
8
4
3
3
1
1
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the middle region of human CA4
Sequence DGEHFAMEMH IVHEKEKGTS RNVKEAQDPE DEIAVLAFLV EAGTQVNEGF
Predicted Reactivity Human: 100%
Characteristics This is a rabbit polyclonal antibody against CA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name CA4 (CA4 Antibody Abstract)
Background Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IV is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and of proximal renal tubules. Its exact function is not known, however, it may have a role in inherited renal abnormalities of bicarbonate transport.
Alias Symbols: CAIV, RP17, Car4
Protein Interaction Partner: PIH1D1, PRDX2, Htt, SLC4A4, SLC4A1, SLC4A3,
Protein Size: 312
Molecular Weight 34 kDa
Gene ID 762
NCBI Accession NM_000717, NP_000708
UniProt P22748
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 312 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-Carbonic Anhydrase IV (CA4) (Middle Region) antibody (ABIN2776799) anti-Carbonic Anhydrase IV (CA4) (Middle Region) antibody
Product cited in: Sun, Yang, Feng, Sun, Zhu, Zhang, Jiang, Li, Gao, Zhang, Wang, Kong, Jin, Fu, Jin: "Temporal and parental-specific expression of imprinted genes in a newly derived Chinese human embryonic stem cell line and embryoid bodies." in: Human molecular genetics, Vol. 15, Issue 1, pp. 65-75, 2005 (PubMed).

Background publications Yang, Alvarez, Chakarova, Jiang, Karan, Frederick, Zhao, Sauvé, Li, Zrenner, Wissinger, Hollander, Katz, Baehr, Cremers, Casey, Bhattacharya, Zhang: "Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration." in: Human molecular genetics, Vol. 14, Issue 2, pp. 255-65, 2004 (PubMed).

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