Ret Proto-Oncogene antibody (C-Term)
-
- Target See all Ret Proto-Oncogene (RET) Antibodies
- Ret Proto-Oncogene (RET)
-
Binding Specificity
- C-Term
-
Reactivity
- Human, Mouse, Rat, Pig, Rabbit, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Dog
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Ret Proto-Oncogene antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- EMKLVHRDLA ARNILVAEGR KMKISDFGLS RDVYEEDSYV KRSQGRIPVK
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 90%, Horse: 100%, Human: 100%, Mouse: 90%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against RET. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product RET Primary Antibody
-
-
- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
-
Antigen size: 1114 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- Ret Proto-Oncogene (RET)
- Alternative Name
- RET (RET Products)
- Synonyms
- c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
- Background
-
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
Alias Symbols: CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51
Protein Interaction Partner: NOTCH2NL, UBC, CBLC, PDLIM7, HSP90AA1, GRB2, CBL, RET, MCRS1, IKBKG, DOK3, DOK5, DOK4, DOK6, SHC3, FRS2, DOK2, AKAP5, CBLB, GAB1, DOK1, NRTN, MAPK3, GRB10, GRB7, GFRA1, MAPK8, GDNF, PTK2, SHC1, MAPK14, SRC, MAPK1, PRKAR2A, PTPN11, PLCG1, PIK3R1, CRK, STAT
Protein Size: 1114 - Molecular Weight
- 123 kDa
- Gene ID
- 5979
- NCBI Accession
- NM_000323, NP_000314
- UniProt
- P07949
- Pathways
- RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
-