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TH antibody (N-Term)

Reactivity: Human, Rat, Mouse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777174
  • Target See all TH products
    TH
    Binding Specificity
    • 16
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    Human, Rat, Mouse, Rabbit, Zebrafish (Danio rerio), Cow, Dog, Guinea Pig, Horse
    Host
    • 39
    • 5
    Rabbit
    Clonality
    • 39
    • 5
    Polyclonal
    Conjugate
    • 27
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TH antibody is un-conjugated
    Application
    • 40
    • 21
    • 19
    • 13
    • 13
    • 7
    • 6
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Sequence
    GAPGPSLTGS PWPGTAAPAA SYTPTPRSPR FIGRRQSLIE DARKEREAAV
    Predicted Reactivity
    Cow: 91%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Characteristics
    This is a rabbit polyclonal antibody against TH. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the n terminal region of human TH
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 528 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    TH
    Abstract
    TH Products
    Synonyms
    DYT14 antibody, DYT5b antibody, TYH antibody, The antibody, tyrosine hydroxylase antibody, TH antibody, Th antibody
    Background
    The specific function of the protein remains unknown. The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
    Alias Symbols: TYH, DYT14, DYT5b
    Protein Interaction Partner: TYSND1, YWHAQ, MAPKAPK2, CDK11B, RPS6KA5, CAMK2G, MAPK3, PRKACA, YWHAB, YWHAZ, MAPK1, SNCA, CSNK2A1,
    Protein Size: 528
    Molecular Weight
    58 kDa
    Gene ID
    7054
    NCBI Accession
    NM_199292, NP_954986
    UniProt
    P07101
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