CBFB antibody (N-Term)
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- Target See all CBFB Antibodies
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Zebrafish (Danio rerio), Horse, Cow, Pig, Rabbit, Dog, Guinea Pig, Saccharomyces cerevisiae
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CBFB antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MPRVVPDQRS KFENEEFFRK LSRECEIKYT GFRDRPHEER QARFQNACRD
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against CBFB. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human CBFB
- Top Product
- Discover our top product CBFB Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 182 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CBFB (Core-Binding Factor, beta Subunit (CBFB))
- Alternative Name
- CBFB (CBFB Products)
- Synonyms
- PEBP2B antibody, Cbfb antibody, pebp2b antibody, Pebp2 antibody, CBFB antibody, unp1266 antibody, cbf-beta antibody, cbfbeta antibody, pea2-beta antibody, pebp2-beta antibody, AI893578 antibody, PEA2 antibody, PEBP2b antibody, Pebpb2 antibody, core-binding factor beta subunit antibody, core binding factor beta subunit antibody, core-binding factor, beta subunit antibody, core-binding factor, beta subunit S homeolog antibody, core binding factor beta antibody, CBFB antibody, Cbfb antibody, cbfb antibody, cbfb.S antibody
- Background
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CBFB encodes a protein that is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.
Alias Symbols: PEBP2B
Protein Interaction Partner: vif, CUL5, UBC, RAB2A, MYC, nef, APOBEC3G, RUNX1, ELAVL1, KMT2A, COPRS, RUNX3, MYOD1, CHGB, CBFA2T2, RUNX2, CBFB, C1QBP,
Protein Size: 182 - Molecular Weight
- 21 kDa
- Gene ID
- 865
- NCBI Accession
- NM_001755, NP_001746
- UniProt
- Q13951
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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