POU4F3 antibody (Middle Region)
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- Target See all POU4F3 Antibodies
- POU4F3 (POU Domain, Class 4, Transcription Factor 3 (POU4F3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This POU4F3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ALANLKIPGV GSLSQSTICR FESLTLSHNN MIALKPVLQA WLEEAEAAYR
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against POU4F3. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human POU4F3
- Top Product
- Discover our top product POU4F3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 338 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- POU4F3 (POU Domain, Class 4, Transcription Factor 3 (POU4F3))
- Alternative Name
- POU4F3 (POU4F3 Products)
- Synonyms
- POU4F3 antibody, BRN-3 antibody, BRN3 antibody, BRN3C antibody, DFNA15 antibody, BRN-3.1 antibody, brn-3c antibody, brn3.1 antibody, brn3c antibody, Brn3.1 antibody, Brn3c antibody, ddl antibody, dreidel antibody, POU class 4 homeobox 3 antibody, POU domain, class 4, transcription factor 3 antibody, POU4F3 antibody, Pou4f3 antibody, pou4f3 antibody
- Background
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POU4F3 is capable of activating both BDNF and NT-3 promoters in inner ear sensory epithelial cell lines. Mutant POU4F3 loses most of its transcriptional activity and most of its ability to bind to DNA. The mutation causes autosomal-dominant nonsyndromic hearing loss and eventually leads to hair cell morbidity in affected family members.
Alias Symbols: BRN3C, DFNA15
Protein Size: 338 - Molecular Weight
- 37 kDa
- Gene ID
- 5459
- NCBI Accession
- NM_002700, NP_002691
- UniProt
- Q15319
- Pathways
- Sensory Perception of Sound
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