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EPC1 antibody (Middle Region)

EPC1 Reactivity: Human, Mouse, Rabbit, Cow, Rat, Dog, Horse, Guinea Pig, Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777875
  • Target See all EPC1 Antibodies
    EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))
    Binding Specificity
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 19
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rabbit, Cow, Rat, Dog, Horse, Guinea Pig, Pig
    Host
    • 18
    • 3
    Rabbit
    Clonality
    • 20
    • 1
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EPC1 antibody is un-conjugated
    Application
    • 11
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VNKQDKADLI RPKRKYEKKP KVLPSSAAAT PQQTSPAALP VFNAKDLNQY
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against EPC1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human EPC1
    Top Product
    Discover our top product EPC1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 836 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))
    Alternative Name
    EPC1 (EPC1 Products)
    Synonyms
    EPC1 antibody, Epl1 antibody, 2400007E14Rik antibody, 5730566F07Rik antibody, A930032N02Rik antibody, epc1 antibody, enhancer of polycomb homolog 1 antibody, enhancer of polycomb homolog 1 (Drosophila) a antibody, enhancer of polycomb homolog 1 (Drosophila) antibody, enhancer of polycomb homolog 1 L homeolog antibody, EPC1 antibody, epc1a antibody, Epc1 antibody, epc1 antibody, epc1.L antibody
    Background
    EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.
    Alias Symbols: DKFZp781P2312, Epl1
    Protein Interaction Partner: RINT1, KRT15, Hopx, TRIM27, H2AFZ, DMAP1, ING3, MORF4L1, KAT5, MYC, MORF4L2, MRGBP, EED, EZH2, E2F6, SRF,
    Protein Size: 836
    Molecular Weight
    93 kDa
    Gene ID
    80314
    NCBI Accession
    NM_025209, NP_079485
    UniProt
    Q9H2F5
    Pathways
    Regulation of Muscle Cell Differentiation
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