NFKB2 antibody (C-Term)
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- Target See all NFKB2 Antibodies
- NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Cow, Pig, Rabbit, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NFKB2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- SDSDSDSEGP EKDTRSSFRG HTPLDLTCST LVKTLLLNAA QNTMEPPL
- Predicted Reactivity
- Cow: 77%, Horse: 85%, Human: 100%, Pig: 77%, Rabbit: 92%, Rat: 77%
- Characteristics
- This is a rabbit polyclonal antibody against NFKB2. It was validated on Western Blot and immunohistochemistry.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human NFKB2
- Top Product
- Discover our top product NFKB2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 933 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity." in: Biochemical and biophysical research communications, Vol. 381, Issue 4, pp. 477-81, (2009) (PubMed).
: "Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis." in: The American journal of pathology, Vol. 171, Issue 1, pp. 326-37, (2007) (PubMed).
: "
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Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity." in: Biochemical and biophysical research communications, Vol. 381, Issue 4, pp. 477-81, (2009) (PubMed).
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- Target
- NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
- Alternative Name
- NFKB2 (NFKB2 Products)
- Synonyms
- NF-kappaB2 antibody, lyt antibody, p49 antibody, p49/p100 antibody, p50B antibody, p52 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 antibody, Nfkb2 antibody
- Background
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NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
Alias Symbols: p52, H2TF1, LYT10, LYT-10
Protein Interaction Partner: FBXW11, UBC, RELB, RELA, REL, NFKB1, CHUK, BCL3, SUMO1, NEDD8, TNFAIP3, BIRC2, EPS8, VCP, UBD, BRRF1, COMMD1, COMMD2, MAP3K14, BTRC, NFKB2, FBXW7, TSG101, IKBKG, SUMO2, DPF2, PSMD11, NFKBIZ, TNIP2, HDAC5, NFKBIB, HDAC4, USP2, NFKBIE, RPL6, IKBKB, TSC22D3,
Protein Size: 900 - Molecular Weight
- 97 kDa
- Gene ID
- 4791
- NCBI Accession
- NM_002502, NP_002493
- UniProt
- Q00653
- Pathways
- Toll-Like Receptors Cascades
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