Osteoactivin (N-Term) antibody

Details for Product No. ABIN2781893, Supplier: Log in to see
Antigen
  • HGFIN
  • NMB
  • DC-HIL
  • Dchil
  • ipd
  • glycoprotein (transmembrane) nmb
  • Gpnmb
  • GPNMB
  • gpnmb
Epitope
N-Term
26
19
16
15
11
9
8
6
5
4
4
3
2
2
2
1
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
129
28
23
4
4
4
3
3
2
2
2
1
1
Host
Rabbit
68
66
1
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
5
5
4
4
4
4
4
4
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
78
59
36
29
16
13
5
3
3
2
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human GPNMB
Blocking Peptide Blocking peptide for this product available: ABIN977597
Sequence DENDWNEKLY PVWKRGDMRW KNSWKGGRVQ AVLTSDSPAL VGSNITFAVN
Specificity 100 % homologous to both isoforms of hGPNMB
Predicted Reactivity Cow: 100%, Dog: 79%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%
Characteristics This is a rabbit polyclonal antibody against GPNMB. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name GPNMB
Background GPNMB is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential.The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HGFIN, NMB
Protein Interaction Partner: UBC, SMAD4, ITSN2,
Protein Size: 560
Molecular Weight 63 kDa
Gene ID 10457
NCBI Accession NM_002510, NP_002501
UniProt Q14956
Research Area Cancer, Innate Immunity
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 560 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Immunohistochemistry (IHC) image for anti-Osteoactivin (N-Term) antibody (ABIN2781893) anti-Osteoactivin (N-Term) antibody
Background publications Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: "Transcriptome analysis of human gastric cancer." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 16, Issue 12, pp. 942-54, 2005 (PubMed).

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