GP6 antibody (Middle Region)

Catalog No. ABIN2782886

Product Details anti-GP6 Antibody

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GP6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against GP6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GP6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 339 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for GP6

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Alternative Name: GP6 (GP6 Products)

Synonyms: BDPLT11 antibody, GPIV antibody, GPVI antibody, 9830166G18Rik antibody, Gm469 antibody, Gpvi antibody, GP6 antibody, glycoprotein VI platelet antibody, glycoprotein 6 (platelet) antibody, glycoprotein VI antibody, platelet glycoprotein VI antibody, GP6 antibody, Gp6 antibody, LOC103346235 antibody

Background: Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].
Alias Symbols: GPIV, GPVI, MGC138168, BDPLT11
Protein Interaction Partner: NCF1, TRAF4, TGFB1I1, LYN, PTK2B, CALM1, FCER1G, YES1, FCGR2A, FCGR3A, FYN, CRP,
Protein Size: 339

Molecular Weight: 37 kDa

Gene ID: 51206

NCBI Accession: NM_016363, NP_057447

UniProt: Q9HCN6