LRP1 antibody (Middle Region)
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- Target See all LRP1 Antibodies
- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
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Binding Specificity
- Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LRP1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ATYLSGAQVS TITPTSTRQT TAMDFSYANE TVCWVHVGDS AAQTQLKCAR
- Characteristics
- This is a rabbit polyclonal antibody against LRP1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human LRP1
- Top Product
- Discover our top product LRP1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 439 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype." in: Journal of lipid research, Vol. 54, Issue 10, pp. 2658-64, (2013) (PubMed).
: "Lead exposure increases levels of ?-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice." in: Neuroscience letters, Vol. 490, Issue 1, pp. 16-20, (2011) (PubMed).
: "Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1." in: Toxicology and applied pharmacology, Vol. 240, Issue 2, pp. 245-54, (2009) (PubMed).
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Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype." in: Journal of lipid research, Vol. 54, Issue 10, pp. 2658-64, (2013) (PubMed).
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- Target
- LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
- Alternative Name
- LRP1 (LRP1 Products)
- Synonyms
- A2MR antibody, APOER antibody, APR antibody, CD91 antibody, IGFBP3R antibody, LRP antibody, LRP1A antibody, TGFBR5 antibody, A2mr antibody, AI316852 antibody, Lrp antibody, LRP-1 antibody, LDL receptor related protein 1 antibody, prolow-density lipoprotein receptor-related protein 1 antibody, low density lipoprotein receptor-related protein 1 antibody, LRP1 antibody, Lrp1 antibody, LOC100414789 antibody
- Background
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Low-density lipoprotein receptor-related protein 1 (.-2-macroglobulin receptor, LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in the extracellular matrix. It is also involved in intracellular signaling and the subcellular translocation of preassembled signaling complexes from the plasma membrane.
Alias Symbols: APR, LRP, A2MR, CD91, APOER, TGFBR5, IGFBP3R
Protein Interaction Partner: UBC, COPS5, APP, RANBP9, SKIL, CHFR, CUBN, FBXO6, ANKS1B, RIC8B, PID1, CC2D1A, MAPRE1, HNRNPDL, MAPK8IP1, SNRNP70, APOE, CACNA1A, USP3, CAV1, MMP14, SHC1, MMP13, SERPINA1, F9, F8, LPL, HSP90B1, SRC, PDGFB, THBS1, SCN3A, PLAUR, PLAT, SERPINE1, MDK, LIPC, L
Protein Size: 439 - Molecular Weight
- 48 kDa
- Gene ID
- 4035
- NCBI Accession
- NM_002332
- UniProt
- Q07954
- Pathways
- Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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