SPANXB1 antibody (Middle Region)

Catalog No. ABIN2788571

Product Details anti-SPANXB1 Antibody

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPANXB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MPETPTGDSD PQPAPKKMKT SESSTILVVR YRRNVKRTSP EELVNDHARE

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against SPANXB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human SPANXB1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPANXB1

Target: SPANXB1 (SPANX Family, Member B1 (SPANXB1))

Alternative Name: SPANXB1 (SPANXB1 Products)

Synonyms: B1 antibody, CT11.2 antibody, SPANX-B antibody, SPANXB antibody, SPANX family member B1 antibody, SPANXB1 antibody

Background: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis.
Alias Symbols: B1, CT11.2, SPANX-B, SPANXB
Protein Interaction Partner: SUMO2,
Protein Size: 103

Molecular Weight: 12 kDa

Gene ID: 728695

NCBI Accession: NM_032461, NP_115850

UniProt: Q9NS25