HIST1H3A antibody (N-Term)

Catalog No. ABIN2788642

Product Details anti-HIST1H3A Antibody

Target: HIST1H3A (Histone Cluster 1, H3a (HIST1H3A))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Saccharomyces cerevisiae, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIST1H3A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KQTARKSTGG KAPRKQLATK AARKSAPATG GVKKPHRYRP GTVALREIRR

Predicted Reactivity: Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against HIST1H3A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HIST1H3A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 136 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HIST1H3A

Target: HIST1H3A (Histone Cluster 1, H3a (HIST1H3A))

Alternative Name: HIST1H3A (HIST1H3A Products)

Synonyms: H3/A antibody, H3FA antibody, histone cluster 1 H3 family member a antibody, histone cluster 1, H3a antibody, HIST1H3A antibody, Hist1h3a antibody

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Alias Symbols: H3/A, H3FA, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J
Protein Interaction Partner: WHSC1, SETD1A, FBLIM1, PRDM2, PRDM6, UBC, H2AFY, H2AFX, HIST1H1B, HIST1H1E, HIST1H1C, BAZ1B, HIST1H2AG, SMARCA5, HIST1H4A, HDAC2, UHRF1, L3MBTL2, GRB2, IRF1, HDAC11, AURKC, RPS6KA3, PAK1, ATXN1, ITGA4, env, CHAF1B, ASF1B, ASF1A, AURKB, CHAF1A, EP300, LRRK
Protein Size: 136

Molecular Weight: 15 kDa

Gene ID: 8350

NCBI Accession: NM_003529, NP_003520

UniProt: P68431