Endothelin 3 antibody (C-Term)
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- Target See all Endothelin 3 (EDN3) Antibodies
- Endothelin 3 (EDN3)
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Binding Specificity
- C-Term
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Reactivity
- Human, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Endothelin 3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LHFCTQTLDV SSNSRTAEKT DKEEEGKVRG ANRGLCQRRL KSRTNKASRL
- Predicted Reactivity
- Human: 100%, Pig: 85%
- Characteristics
- This is a rabbit polyclonal antibody against EDN3. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human EDN3
- Top Product
- Discover our top product EDN3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 219 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Endothelin 3 (EDN3)
- Alternative Name
- EDN3 (EDN3 Products)
- Synonyms
- et-3 antibody, EDN3 antibody, ET-3 antibody, ET3 antibody, HSCR4 antibody, PPET3 antibody, WS4B antibody, 114CH19 antibody, ls antibody, tmgc48 antibody, Et3 antibody, RGD1564825 antibody, preproET-3 antibody, endothelin-3 L homeolog antibody, endothelin 3 antibody, edn3.L antibody, EDN3 antibody, Edn3 antibody
- Background
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The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
Alias Symbols: ET3, MGC15067, MGC61498, ET-3, WS4B, HSCR4, PPET3
Protein Interaction Partner: EDNRB, EDNRA, CMA1, CTSE, KEL,
Protein Size: 219 - Molecular Weight
- 24 kDa
- Gene ID
- 1908
- NCBI Accession
- NM_207032, NP_996915
- UniProt
- P14138
- Pathways
- Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones
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