WWOX antibody (C-Term)
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- Target See all WWOX Antibodies
- WWOX (WW Domain Containing Oxidoreductase (WWOX))
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Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WWOX antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- DDNPTKPTTR QRYDGSTTAM EILQGRDFTG KVVVVTGANS GIGFETAKSF
- Predicted Reactivity
- Cow: 100%, Dog: 92%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against WWOX. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product WWOX Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 189 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- WWOX (WW Domain Containing Oxidoreductase (WWOX))
- Alternative Name
- WWOX (WWOX Products)
- Synonyms
- CG7221 antibody, DmWWOX antibody, Dmel\\CG7221 antibody, anon-EST:Posey177 antibody, GB11795 antibody, WWOX antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody, zgc:55975 antibody, 5330426P09Rik antibody, 9030416C10Rik antibody, WW domain containing oxidoreductase antibody, WW domain-containing oxidoreductase antibody, Wwox antibody, LOC411815 antibody, WWOX antibody, CpipJ_CPIJ004939 antibody, MCYG_01584 antibody, VDBG_05631 antibody, VDBG_01326 antibody, VDBG_06753 antibody, Tsp_03967 antibody, LOC100284583 antibody, wwox antibody
- Background
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WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.
Alias Symbols: D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Protein Interaction Partner: ITCH, TRIM28, HUWE1, UBC, ATM, RPRD2, CYFIP1, SPG20, SNRNP200, ACIN1, SLC4A1AP, DHX30, SCAF8, XRN2, GABARAPL2, SEC23IP, HNRNPUL1, DIDO1, CPSF6, SF3B2, SF3A3, SRSF10, USP39, IGF2BP2, IGF2BP3, IGF2BP1, PAICS, PRPF8, CCT2, CCT7, NOP56, DDX17, SEC23A, BAIAP2,
Protein Size: 189 - Molecular Weight
- 21 kDa
- Gene ID
- 51741
- NCBI Accession
- NM_130791, NP_570607
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