MCAM antibody (Middle Region)
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- Target See all MCAM Antibodies
- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Rabbit, Pig, Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MCAM antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- PSTREAEEET TNDNGVLVLE PARKEHSGRY ECQGLDLDTM ISLLSEPQEL
- Predicted Reactivity
- Cow: 86%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 79%
- Characteristics
- This is a rabbit polyclonal antibody against MCAM. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product MCAM Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 646 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MCAM (Melanoma Cell Adhesion Molecule (MCAM))
- Alternative Name
- MCAM (MCAM Products)
- Synonyms
- CD146 antibody, MUC18 antibody, Muc18 antibody, 1-gicerin antibody, AV025631 antibody, CD149 antibody, s-endo antibody, s-gicerin antibody, cd146 antibody, gicerin antibody, id:ibd3512 antibody, mcam antibody, MCAM antibody, melanoma cell adhesion molecule antibody, melanoma cell adhesion molecule b antibody, MCAM antibody, Mcam antibody, mcamb antibody
- Background
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MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. MCAM could be an adhesion molecule active in neural crest cells during embryonic development. MCAM acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Alias Symbols: CD146, MUC18
Protein Interaction Partner: ADRB2, UBC, HSP90AA5P, HSPA1L, ATF7IP, PTK2B, FYN,
Protein Size: 646 - Molecular Weight
- 71 kDa
- Gene ID
- 4162
- NCBI Accession
- NM_006500, NP_006491
- UniProt
- P43121
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