MMP25 antibody (Middle Region)
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- Target See all MMP25 Antibodies
- MMP25 (Matrix Metallopeptidase 25 (MMP25))
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Binding Specificity
- Middle Region
- Reactivity
- Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MMP25 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- FGHALGLGHS SAPNSIMRPF YQGPVGDPDK YRLSQDDRDG LQQLYGKAPQ
- Predicted Reactivity
- Dog: 82%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 100%, Rat: 92%
- Characteristics
- This is a rabbit polyclonal antibody against MMP25. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product MMP25 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 562 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MMP25 (Matrix Metallopeptidase 25 (MMP25))
- Alternative Name
- MMP25 (MMP25 Products)
- Synonyms
- MMP-25 antibody, MMP20 antibody, MMP20A antibody, MMPL1 antibody, MT-MMP 6 antibody, MT-MMP6 antibody, MT6-MMP antibody, MT6MMP antibody, MTMMP6 antibody, F730048C11Rik antibody, Leukolysin antibody, matrix metallopeptidase 25 antibody, MMP25 antibody, Mmp25 antibody
- Background
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Alias Symbols: MMP20, MMP20A, MMPL1, MT-MMP6, MT6-MMP
Protein Interaction Partner: CLU, MMP2,
Protein Size: 562 - Molecular Weight
- 48 kDa
- Gene ID
- 64386
- NCBI Accession
- NM_022468, NP_071913
- UniProt
- Q9NPA2
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