SPG21 antibody (C-Term)
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- Target See all SPG21 Antibodies
- SPG21 (Spastic Paraplegia 21 (SPG21))
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Binding Specificity
- C-Term
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Reactivity
- Human, Cow, Dog, Guinea Pig, Horse, Mouse, Rabbit, Rat, Sheep, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SPG21 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- IPVTIMDVFD QSALSTEAKE EMYKLYPNAR RAHLKTGGNF PYLCRSAEVN
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against SPG21. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPG21
- Top Product
- Discover our top product SPG21 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 308 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SPG21 (Spastic Paraplegia 21 (SPG21))
- Alternative Name
- SPG21 (SPG21 Products)
- Synonyms
- ACP33 antibody, GL010 antibody, MAST antibody, BM-019 antibody, C78576 antibody, D9Wsu18e antibody, Maspardin antibody, wu:fd07h02 antibody, zgc:73091 antibody, SPG21, maspardin antibody, spastic paraplegia 21 (autosomal recessive, Mast syndrome) antibody, SPG21, maspardin S homeolog antibody, SPG21 antibody, Spg21 antibody, spg21.S antibody, spg21 antibody
- Background
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The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene.
Alias Symbols: ACP33, BM-019, GL010, MASPARDIN, MAST
Protein Interaction Partner: INCA1, SPRED2, DTX3L, CMTM5, TRIM9, DTX2, REEP6, FAM114A1, ATPAF2, EFHC2, CCDC33, CCDC102B, TRIM54, AGTRAP, CTPS2, S100B, PRPS1, KRT15, CRYAA, TRIM23, CUTC, ARL6IP1, IKZF3, MID2, RABAC1, TFG, TRAF2, TRAF1, TCF12, TCF4, UBC, GSK3A, DHX40, YLPM1, HMGCS1, AK
Protein Size: 308 - Molecular Weight
- 35 kDa
- Gene ID
- 51324
- NCBI Accession
- NM_016630, NP_057714
- UniProt
- Q9NZD8
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