DOK1 antibody (C-Term)
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- Target See all DOK1 Antibodies
- DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DOK1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EPGTATGSGI KSHNSALYSQ VQKSGASGSW DCGLSRVGTD KTGVKSEGST
- Predicted Reactivity
- Horse: 84%, Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against DOK1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1
- Top Product
- Discover our top product DOK1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 481 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- DOK1 (Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1))
- Alternative Name
- DOK1 (DOK1 Products)
- Synonyms
- P62DOK antibody, Dok-1 antibody, AW557123 antibody, p62DOK antibody, dok1 antibody, zgc:76914 antibody, docking protein 1 antibody, docking protein 1b antibody, DOK1 antibody, Dok1 antibody, dok1b antibody
- Background
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DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Alias Symbols: MGC117395, MGC138860, P62DOK
Protein Interaction Partner: UBC, RASA1, ABL1, CD28, Nck1, Syngap1, INSR, CRKL, BCR, Dlg4, gag-pol, ERBB2, VAV1, SRC, SHC1, PTK6, PIK3R1, ITK, FGR, CRK, ABL2, CBLL1, INPP5D, NCK2, MAP4K4, PTPRH, GRB10, TEC, ITGB2, SH2D1A, FES, PTPN6, ITGB3, PLCG1, LYN, KIT, YES1, RET, LCK, ITGB5, ITG
Protein Size: 481 - Molecular Weight
- 53 kDa
- Gene ID
- 1796
- NCBI Accession
- NM_001381, NP_001372
- UniProt
- Q99704
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