SLC7A5 antibody

Catalog No. ABIN289962

Product Details anti-SLC7A5 Antibody

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC7A5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: This antidody was purified from rabbit serum immunized with synthesized peptide ofC- end of human LAT1 and has been proved to be useful for the immunohistochemistry

Immunogen: Partial peptide of Human L-type Amino Acid Transporter 1(LAT1)

Application Details

Application Notes: Working dilution for immunohistochemistry: 5-10ug/ml

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for SLC7A5

Target: SLC7A5 (Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 5 (SLC7A5))

Alternative Name: L-type Amino Acid Transporter 1(LAT1) (SLC7A5 Products)

Synonyms: 4F2LC antibody, CD98 antibody, D16S469E antibody, E16 antibody, LAT1 antibody, MPE16 antibody, hLAT1 antibody, D0H16S474E antibody, TA1 antibody, JHI-21 antibody, SLC7A5 antibody, LAT-1 antibody, slc7a5a antibody, 4F2 antibody, 4F2HC antibody, AI314110 antibody, Cd98 antibody, Ly-10 antibody, Ly-m10 antibody, Ly10 antibody, Mdu1 antibody, Mgp-2hc antibody, NACAE antibody, solute carrier family 7 member 5 antibody, solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 antibody, solute carrier family 7 (amino acid transporter light chain, L system), member 5 antibody, solute carrier family 7 member 5 S homeolog antibody, solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 antibody, SLC7A5 antibody, Slc7a5 antibody, slc7a5.S antibody, Slc3a2 antibody

Background: Mammalian amino acid transport system is consisted of large variety of transporters, with the reflection ofamino acid molecule variety, and is classfied into various transport systems by the transportative substrateselectivity and the Na+ dependence with the reflection of amino acid molecule variety.L-type amino acid transporter 1 (LAT1) is a predicted 12 membrane-spanning protein and is uniquebecause it requires an additional single membrane spanning protein, 4F2 heavy chain (4F2hc:CD98), for itsfunctional expression. L-type is Na+ -independent neutral amino acid transporter agency and essential forthe transporter of large neutral amino acid such as Leucine, Isoleucine, Varine through the plasmamembrane. LAT1 is, thus transporter responsible for the permeation of aromatic or branched-chain aminoacids and amino acid-related drugs such as L-DOPA. LAT has been proposed to be one of the majornutrient transport systems at the blood-brain barrier. Highly regulated nature and high level of expression intumor cell lines, LAT is thought to be up-regulated to support the high protein synthesis for cell glowth andcell activation.This antibody has been proved to be useful for the immunohistochemistry.