Transferrin Receptor antibody

Catalog No. ABIN290057

Product Details anti-Transferrin Receptor Antibody

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Purification: Protein G

Immunogen: human cancer cel line

Clone: YUK9

Isotype: IgG1 kappa

Application Details

Application Notes: WB Not tested. IHC Not tested. ICC Not tested. ELISA Not tested. FCM 1.0-5.0 ug/ml. Neutralization Not tested. IP 5.0-10.0 ug/ml

Restrictions: For Research Use only

Handling

Concentration: 0.25 mg/ml

Buffer: PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)

Preservative: ProClin

Storage: -20 °C

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: CD71 (TFRC) (TFRC Products)

Synonyms: Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody

Background: CD71 (also known as TFRC: transferrin receptor) is a widely expressed 180 kDa type II membrane glycoprotein involved in the cellular uptake of iron and inthe regulation of cell growth. Iron uptake occurs via the internalization of iron-loaded transferrin mediated by the interaction with the CD71. CD71expression is increased on rapidly proliferating cells, while expression is decreased or absent on non-dividing cells. Some studies have suggested thatbiologically aggressive tumors require large amounts of iron for active metabolism and rapid cell growth, and overexpression of CD71 has reported indifferent types of cancers such as glioma, pancreatic, and colon cancers.In addition, CD71 is required for adult erythropoiesis and involved in T- and B- cell development. CD71 seems to play an important role in T cell activation,and T cells lacking CD71 are completely arrested at a very early stage of maturation.This antibody is specific to human CD71 and will be useful for FCM, immunoprecipitation.

Pathways: Transition Metal Ion Homeostasis