TNFRSF10B antibody (Extracellular Domain)

Catalog No. ABIN294044

The Mouse Monoclonal anti-TNFRSF10B antibody is suitable to detect TNFRSF10B in samples from Human. It has been validated for FACS.

Quick Overview for TNFRSF10B antibody (Extracellular Domain) (ABIN294044)

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: DR5-01-1

Product Details anti-TNFRSF10B Antibody

Binding Specificity: Extracellular Domain

Specificity: Recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L)

Purification: Protein A purified

Immunogen: Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.

Type of Immunogen: Fusion protein

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1 - 10 μg/mL)

Usage: Flow Cytometry: Recommended dilution - 1-10 μg/mL. Positive control - JURKAT human peripheral blood leukemia T cell line.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 15 mM sodium azide, approx,  pH 7.4.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Alternative Name: TNFRSF10B / Killer / DR5

Background: Name/Gene ID: TNFRSF10B
Family: TNF Receptor

Synonyms: TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9

Gene ID: 8795

UniProt: O14763

Pathways: p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity