CD11c antibody

Catalog No. ABIN294215

Product Details anti-CD11c Antibody

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11c antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: Recognizes human CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95, a 150kD type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells. CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen. Clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. Does not recognize CD11a, CD11b or CD18.

Purification: Affinity purified

Immunogen: Recombinant human CD11c.

Type of Immunogen: Recombinant protein

Clone: CBR-p150-4G1

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, Func, IHC, IHC-Fr (5 - 10 μg/mL), IP

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS.

Preservative: Azide free

Storage: -20 °C

Storage Comment: Short term: -20°C
Long term: -20°C.

Target Details for CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Alternative Name: ITGAX / CD11c (ITGAX Products)

Synonyms: CD11C antibody, SLEB6 antibody, RGD1561123 antibody, AI449405 antibody, Cd11c antibody, Cr4 antibody, N418 antibody, integrin subunit alpha X antibody, integrin alpha X antibody, ITGAX antibody, Itgax antibody

Background: Name/Gene ID: ITGAX
Family: Integrin

Synonyms: ITGAX, CD11c antigen, Integrin alpha-X, Leu M5, alpha subunit, p150 95 integrin alpha chain, SLEB6, CD11C, Leu M5

Gene ID: 3687

UniProt: P20702

Pathways: Complement System, Activated T Cell Proliferation, Integrin Complex