CLEC4E antibody (C-Term)

Catalog No. ABIN3024557

Product Details anti-CLEC4E Antibody

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLEC4E antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Protein A affinity chromatography

Immunogen: A recombinant protein fragment from the C-terminal portion of human CLEC4E was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: Provided assay concentrations are suggestions only, CLEC4E antibody titration may be required for optimal results.\. Western blot: 2-5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: 0.5 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CLEC4E antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CLEC4E

Target: CLEC4E (C-Type Lectin Domain Family 4, Member E (CLEC4E))

Alternative Name: CLEC4E (CLEC4E Products)

Synonyms: CLECSF9 antibody, MINCLE antibody, C86253 antibody, Clecsf9 antibody, Mincle antibody, CLEC4E antibody, C-type lectin domain family 4 member E antibody, C-type lectin domain family 4, member e antibody, C-type lectin domain family 4, member E antibody, CLEC4E antibody, Clec4e antibody, LOC611538 antibody

Background: CLEC4 is a member of the C-type lectin family of proteins that plays a role in inflammatory and immune response. CLEC4E, also called Mincle (Macrophage-inducible C-type lectin), is found on the surface of activated macrophages and phagocytes. It is a receptor for both non-self (fungi and mycobacteria), and self (damaged cells) ligands. Dead cells release SAP130 (Sin3A-Associated Protein, 130  kDa), a small nuclear ribonucleoprotein component. CLEC4E senses this and interacts with the ITAM-containing adaptor protein FcRgamma, and via Syk and CARD9 signaling, activates the production of inflammatory cytokines such as TNFa, MIP-2 and IL-6.

Gene ID: 26253