GRIN2C antibody (AA 43-242)

Catalog No. ABIN3042433

Product Details anti-GRIN2C Antibody

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Binding Specificity: AA 43-242

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIN2C antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 2C(GRIN2C) detection. Tested with WB in Human,Rat.

Cross-Reactivity (Details): Predicted Cross Reactivity: human
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, NMDA 2C(GRIN2C) detection. Tested with WB in Human,Rat.
Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Protein Name: Glutamate receptor ionotropic, NMDA 2C

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NMDAR2C recombinant protein (Position: Q43-Q242). Human NMDAR2C shares 93% and 92.5% amino acid (aa) sequence identity with mouse and rat NMDAR2C, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, The detection limit for NMDAR2C is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for GRIN2C

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Alternative Name: GRIN2C (GRIN2C Products)

Synonyms: GRIN2C antibody, NMDAR2C antibody, il12rb2l antibody, il-12rb2.b antibody, nr2c antibody, GluN2C antibody, NR2C antibody, glutamate ionotropic receptor NMDA type subunit 2C antibody, interleukin 12 receptor, beta 2a, like antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C S homeolog antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 2C antibody, glutamate receptor, ionotropic, NMDA2C (epsilon 3) antibody, GRIN2C antibody, il12rb2l antibody, grin2c.S antibody, grin2c antibody, Grin2c antibody

Background: NMDAR2C, known as GRIN2C, is mapped to 17q25.1. Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants.

Synonyms: GluN2C antibody|Glutamate [NMDA] receptor subunit epsilon-3 antibody|Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody|Glutamate receptor ionotropic, NMDA 2C antibody|Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody|Grin2c antibody|N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody|N Methyl D Aspartate Receptor Subtype 2C antibody|N methyl D aspartate receptor subunit 2C antibody|N-methyl D-aspartate receptor subtype 2C antibody|NMDAR2C antibody|NMDE3_HUMAN antibody|NR2C antibody|OTTHUMP00000041930 antibody

Gene ID: 2905

UniProt: Q14957

Pathways: Synaptic Membrane