PPIB antibody (C-Term)

Catalog No. ABIN3042869

Product Details anti-PPIB Antibody

Target: PPIB (Cyclophilin B (PPIB))

Binding Specificity: AA 176-196, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPIB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase B(PPIB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: MEVVRKVEST KTDSRDKPLK D

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase B(PPIB) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: peptidylprolyl isomerase B(cyclophilin B)
Protein Name: Peptidyl-prolyl cis-trans isomerase B

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cyclophilin B(176-196aa MEVVRKVESTKTDSRDKPLKD), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, The detection limit for PPIB is approximately 1.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Predicted Species: Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PPIB

Target: PPIB (Cyclophilin B (PPIB))

Alternative Name: PPIB (PPIB Products)

Synonyms: cypb antibody, scylp antibody, cyp-s1 antibody, PPIB antibody, Ppib antibody, ACYPI004891 antibody, AA408962 antibody, AA553318 antibody, AI844835 antibody, Cphn-2 antibody, Cphn2 antibody, CyP-20b antibody, CypB antibody, Scylp antibody, CYP-S1 antibody, CYPB antibody, OI9 antibody, SCYLP antibody, cb87 antibody, sb:cb87 antibody, wu:fa97f08 antibody, zgc:73214 antibody, zgc:86796 antibody, peptidylprolyl isomerase B antibody, peptidylprolyl isomerase B (cyclophilin B) antibody, peptidylprolyl isomerase B L homeolog antibody, ppib antibody, PPIB antibody, Ppib antibody, CC1G_03223 antibody, ppib.L antibody

Background: Peptidyl-prolyl cis-trans isomerase B, also known as CYPB, is an enzyme that in humans is encoded by the PPIB gene. This gene is mapped to 15q22.31. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

Synonyms: AA408962 antibody|AA553318 antibody|AI844835 antibody|Cphn 2 antibody|Cphn2 antibody|Cyclophilin B antibody|Cyclophilin like protein antibody|CyP 20b antibody|CYP S1 antibody|CYP-S1 antibody|CYPB antibody|EC 5.2.1.8 antibody|MGC14109 antibody|MGC2224 antibody|OI9 antibody|peptidyl prolyl cis trans isomerase B antibody|Peptidyl prolyl cis trans isomerase B precursor antibody|Peptidyl-prolyl cis-trans isomerase B antibody|Peptidyl-prolyl cis-trans isomerase B precursor antibody|peptidylprolyl isomerase B(cyclophilin B) antibody|Peptidylprolyl isomerase B antibody|PPIase antibody|PPIase B antibody|PPIB antibody|PPIB_HUMAN antibody|Rotamase antibody|Rotamase B antibody|S cyclophilin antibody|S-cyclophilin antibody|SCYLP antibody

UniProt: P23284