DPYD antibody (N-Term)

Catalog No. ABIN3044151

Product Details anti-DPYD Antibody

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Binding Specificity: AA 33-52, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYD antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.

Sequence: AKKLDKKHWK RNPDKNCFNC

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Dihydropyrimidine dehydrogenase[NADP(+)](DPYD) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: dihydropyrimidine dehydrogenase
Protein Name: Dihydropyrimidine dehydrogenase [NADP(+)](DHPDHase/DPD)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human DPYD(33-52aa AKKLDKKHWKRNPDKNCFNC), different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for DPYD

Target: DPYD (Dihydropyrimidine Dehydrogenase (DPYD))

Alternative Name: DPYD (DPYD Products)

Synonyms: DPYD antibody, dpyd antibody, zgc:77205 antibody, AI315208 antibody, DPD antibody, E330028L06Rik antibody, DHP antibody, DHPDHASE antibody, dhp antibody, dhpdhase antibody, dpd antibody, 14.t00017 antibody, DDBDRAFT_0189681 antibody, DDBDRAFT_0231100 antibody, DDB_0189681 antibody, DDB_0231100 antibody, dpyda antibody, zgc:153505 antibody, dihydropyrimidine dehydrogenase antibody, dihydropyrimidine dehydrogenase b antibody, dihydropyrimidine dehydrogenase L homeolog antibody, dihydropyrimidine dehydrogenase [NADP(+)] antibody, dihydropyrimidine dehydrogenase a, tandem duplicate 1 antibody, DPYD antibody, Dpyd antibody, dpydb antibody, dpyd.L antibody, EHI_012980 antibody, LOC5573038 antibody, EDI_044620 antibody, pyd1 antibody, dpyda.1 antibody

Background: DPYD(Dihydropyrimidine Dehydrogenase), also called DPD, is an enzyme that in humans is encoded by the DPYD gene. The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. The structure of the DPYD gene contains 23 exons spanning about 950 kb. Using somatic cell hybrid strategies, the DPYD gene is mapped to the centromeric region of chromosome 1 between 1p22 and 1q21. By fluorescence in situ hybridization, the DPYD gene is mapped to 1p22. The highest level of DPD was found in monocytes followed by that in lymphocytes, granulocytes, and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in peripheral blood mononuclear cells was intermediate between that observed in monocytes and lymphocytes. By cDNA microarray, Western blot analysis, and luciferase reporter assay, the transcription factor LSF was identified as a positive regulator of DPYD.

Synonyms: DHP antibody|DHPDHase antibody|Dihydropyrimidine dehydrogenase[NADP(+)] antibody|Dihydropyrimidine dehydrogenase[NADP+] antibody|Dihydropyrimidine dehydrogenase antibody|Dihydrothymine dehydrogenase antibody|Dihydrouracil dehydrogenase antibody|DPD antibody|DPYD antibody|DPYD_HUMAN antibody|MGC132008 antibody|MGC70799 antibody|OTTHUMP00000058954 antibody

UniProt: Q12882

Pathways: Ribonucleoside Biosynthetic Process