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TLE2 antibody (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)) (N-Term)

Details for Product anti-TLE2 Antibody No. ABIN309653, Supplier: Login to see New
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Antigen
Synonyms TLE2, ESG, ESG2, GRG2, Grg2, mKIAA4188
Alternatives
Epitope
N-Term
(17), (16), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(30), (18), (1)
Host
Rabbit
(40), (4), (1)
Clonality
Polyclonal
Conjugate
This TLE2 antibody is un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(42), (26), (6), (3), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human TLE2
Blocking Peptide Blocking peptide for this product available: ABIN985126
Sequence VEEERPSGPG GGGKQRADEK EPSGPYESDE DKSDYNLVVD EDQPSEPPSP
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against TLE2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TLE2 (TLE2 Antibody Abstract)
Background TLE2 belongs to the WD repeat Groucho/TLE family. It contains 6 WD repeats. TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
Molecular Weight 80 kDa
Gene ID 7089
NCBI Accession NM_003260, NP_003251
UniProt Q04725
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Pathways WNT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 743 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-TLE2 antibody (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)) (N-Term) (ABIN309653) anti-Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila) (TLE2) (N-Term) antibody
Background publications Higa, Wu, Ye et al.: "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation." in: Nature cell biology, Vol. 8, Issue 11, pp. 1277-83, 2006 (PubMed).

Catalog No. ABIN309653
$289.00
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