Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody

Details for Product No. ABIN309708
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Antigen
Synonyms TOX1, 1700007F02Rik
Epitope
N-Term
(9), (1)
Reactivity
Mouse (Murine), Dog (Canine), Rat (Rattus), Cow (Bovine), Human, Chicken
(10), (2), (2), (2), (2), (2)
Host
Rabbit
(10)
Clonality
Polyclonal
Application
Western Blotting (WB)
(10), (6), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN309708
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human TOX
Sequence CLDPYYCNKF DGENMYMSMT EPSQDYVPAS QSYPGPSLES EDFNIPPITP
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Chicken : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against TOX. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TOX
Background Some high-mobility group (HMG) box proteins (e.g., LEF1) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMG1) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. All HMG box proteins are able to induce a sharp bend in DNA. TOX contains a single HMG box motif.Some high-mobility group (HMG) box proteins (e.g., LEF1, MIM 153245) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMG1, MIM 163905) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. All HMG box proteins are able to induce a sharp bend in DNA. TOX contains a single HMG box motif.
Molecular Weight 58 kDa
Gene ID 9760
NCBI Accession NP_055544, NM_014729
UniProt O94900
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 526 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody WB Suggested Anti-TOX Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
anti-Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody (2) WB Suggested Anti-TOX
Antibody Titration: 0.2-1 µg/mL
Positive Control: Jurkat cell lysate
TOX is supported by BioGPS gene expression data to be expressed in Jurkat
Background publications Aliahmad, OFlaherty, Han et al.: "TOX provides a link between calcineurin activation and CD8 lineage commitment." in: The Journal of experimental medicine, Vol. 199, Issue 8, pp. 1089-99, 2004 (PubMed).

Validation Images
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