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Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody

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Antigen
Synonyms TOX1, 1700007F02Rik
Epitope
N-Term
(9), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(15), (8), (3), (2), (2), (2)
Host
Rabbit
(15), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1)
Application
Western Blotting (WB)
(15), (4), (3), (3), (3), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human TOX
Blocking Peptide Blocking peptide for this product available: ABIN985381
Sequence CLDPYYCNKF DGENMYMSMT EPSQDYVPAS QSYPGPSLES EDFNIPPITP
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Chicken : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against TOX. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TOX (TOX Antibody Abstract)
Background Some high-mobility group (HMG) box proteins (e.g., LEF1) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMG1) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. All HMG box proteins are able to induce a sharp bend in DNA. TOX contains a single HMG box motif.Some high-mobility group (HMG) box proteins (e.g., LEF1, MIM 153245) contain a single HMG box motif and bind DNA in a sequence-specific manner, while other members of this family (e.g., HMG1, MIM 163905) have multiple HMG boxes and bind DNA in a sequence-independent but structure-dependent manner. All HMG box proteins are able to induce a sharp bend in DNA. TOX contains a single HMG box motif.
Molecular Weight 58 kDa
Gene ID 9760
NCBI Accession NP_055544, NM_014729
UniProt O94900
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 526 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody (ABIN309708) WB Suggested Anti-TOX Antibody Titration: 0.2-1 ug/ml
Positive Control: ...
Western Blotting (WB) image for anti-Thymus High Mobility Group Box Protein (TOX) (N-Term) antibody (ABIN309708) WB Suggested Anti-TOX
Antibody Titration: 0.2-1 µg/mL
Positive Control:...
Background publications Aliahmad, OFlaherty, Han et al.: "TOX provides a link between calcineurin activation and CD8 lineage commitment." in: The Journal of experimental medicine, Vol. 199, Issue 8, pp. 1089-99, 2004 (PubMed).

Catalog No. ABIN309708
$289.00
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