TIA1 Cytotoxic Granule-Associated RNA Binding Protein (TIA1) (C-Term) antibody

Details for Product No. ABIN310093
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Antigen
Synonyms tia1, 2310050N03Rik, AI256674, TIA-1, mTIA-1, WDM, TIAL1, TIAR, tia-1
Epitope
C-Term
(6), (4), (3), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Human, Chicken
(37), (19), (16), (14), (11), (1), (1), (1)
Host
Rabbit
(24), (8), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (9), (9), (8), (3), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310093
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human TIA1
Sequence QAWNQQGFNQ TQSSAPWMGP NYGVQPPQGQ NGSMLPNQPS GYRVAGYETQ
Predicted Reactivity Human : 100 %, Dog : 90 %, Horse : 90 %, Mouse : 90 %, Rabbit : 90 %, Rat : 90 %, Chicken : 70 %
Characteristics This is a rabbit polyclonal antibody against TIA1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name TIA1
Background TIA1 is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing.The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Molecular Weight 42 kDa
Gene ID 7072
NCBI Accession NP_071320, NM_022037
Research Area Chromatin and Nuclear Signaling, DNA/RNA, Adaptive Immunity, Apoptosis/Necrosis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 375 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications López de Silanes, Galbán, Martindale et al.: "Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9520-31, 2005 (PubMed).

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