RAD23 Homolog A (S. Cerevisiae) (RAD23A) (Middle Region) antibody

Details for Product No. ABIN310302
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Antigen
Synonyms rad23a, wu:fe11h06, zgc:92001, RAD23A, HHR23A, HR23A, 2310040P19Rik, AL024030, mHR23A
Epitope
Middle Region
(7), (6), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Human
(59), (12), (6), (3), (1), (1)
Host
Rabbit
(52), (6), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (37), (17), (7), (6), (2), (2), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN310302
229.00 $
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Immunogen Synthetic peptide directed towards the middle region of human RAD23A
Sequence GIPGSPEPEH GSVQESQVSE QPATEAAGEN PLEFLRDQPQ FQNMRQVIQQ
Predicted Reactivity Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Guinea pig : 90 %
Characteristics This is a rabbit polyclonal antibody against RAD23A. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name RAD23A
Background RAD23A is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
Molecular Weight 40 kDa
Gene ID 5886
NCBI Accession NM_005053, NP_005044
UniProt P54725
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 363 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-RAD23 Homolog A (S. Cerevisiae) (RAD23A) (Middle Region) antibody WB Suggested Anti-RAD23A Antibody Titration: 2.5ug/ml
Positive Control: Jurkat cell lysate
anti-RAD23 Homolog A (S. Cerevisiae) (RAD23A) (Middle Region) antibody (2) anti-RAD23 Homolog A (S. Cerevisiae) (RAD23A) (Middle Region) antibody (Image 2)
Background publications Ju, Xie: "A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23." in: Biochemical and biophysical research communications, Vol. 341, Issue 2, pp. 648-52, 2006 (PubMed).

Validation Images
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