Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (C-Term) antibody

Details for Product No. ABIN310418
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Antigen
Synonyms CDC23, anaphase-promoting complex subunit 8, zgc:56013, 6030435O18, D18Ertd243e, ANAPC8, APC8, CUT23
Epitope
C-Term
(9), (8), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Dog (Canine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Human
(48), (34), (26), (15), (13), (12), (12), (1), (1), (1)
Host
Rabbit
(48), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(37), (22), (10), (9), (8), (3), (2), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310418
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human CDC23
Sequence DTREEGKALL RQILQLRNQG ETPTTEVPAP FFLPASLSAN NTPTRRVSPL
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against CDC23. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CDC23
Background CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Molecular Weight 65 kDa
Gene ID 8697
NCBI Accession NP_004652, NM_004661
UniProt Q9UJX2
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 591 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (C-Term) antibody WB Suggested Anti-CDC23 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
anti-Cell Division Cycle 23 Homolog (S. Cerevisiae) (CDC23) (C-Term) antibody (2) WB Suggested Anti-CDC23
Antibody Titration: 0.2-1 µg/mL
Positive Control: Jurkat cell lysate
CDC23 is supported by BioGPS gene expression data to be expressed in Jurkat
Background publications Beausoleil, Jedrychowski, Schwartz et al.: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).

Validation Images
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