PGD Synthetase (PGDS) (N-Term) antibody

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Antigen
Synonyms 21kDa, L-PGDS, PGD2, PGDS, PGDS2, Ptgs3, PH2DISO, LPGDS, PDS
Epitope
N-Term
(5), (3), (3), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(11), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(9), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(10), (2), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human PGDS
Blocking Peptide Blocking peptide for this product available: Hematopoietic Prostaglandin D Synthase (HPGDS) peptide (ABIN981636)
Sequence PNYKLTYFNM RGRAEIIRYI FAYLDIQYED HRIEQADWPE IKSTLPFGKI
Predicted Reactivity Human : 100 %, Bovine : 90 %, Dog : 90 %, Mouse : 90 %, Pig : 90 %, Rat : 90 %
Characteristics This is a rabbit polyclonal antibody against PGDS. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PGDS (PGDS Antibody Abstract)
Background PGDS is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
Molecular Weight 23 kDa
Gene ID 27306
NCBI Accession NP_055300, NM_014485
UniProt O60760
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 199 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-PGD Synthetase (PGDS) (N-Term) antibody (ABIN311077) WB Suggested Anti-PGDS Antibody Titration: 0.2-1 ug/ml
Positive Control:...
Background publications Inoue, Okano, Kado et al.: "First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase." in: Journal of biochemistry, Vol. 135, Issue 3, pp. 279-83, 2004 (PubMed).

Catalog No. ABIN311077
$289.00
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