CD11c antibody

Catalog No. ABIN317135

Product Details anti-CD11c Antibody

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD11c antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Specificity: This antibody specifically recognises CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95. Clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. This antibody does not recognise CD11a, CD11b or CD18.

Characteristics: Synonyms: Integrin alpha-X, Leu-M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain,Leukocyte adhesion receptor p150, 95, CD11 antigen-like family member C

Purification: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Recombinant human CD11c

Clone: CBR-p150-4G1

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry. Immunohistochemistry on frozen sections: 5 - 10g/mL. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline

Preservative: Azide free

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD11c

Target: CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))

Alternative Name: CD11c (ITGAX Products)

Synonyms: CD11C antibody, SLEB6 antibody, RGD1561123 antibody, AI449405 antibody, Cd11c antibody, Cr4 antibody, N418 antibody, integrin subunit alpha X antibody, integrin alpha X antibody, ITGAX antibody, Itgax antibody

Background: CD11c is a 150 kDa type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells. CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen.Synonyms: CD11 antigen-like family member C, ITGAX, Integrin alpha-X, Leu M5, Leukocyte adhesion glycoprotein p150 95 alpha chain, Leukocyte adhesion receptor p150 95

Gene ID: 3687

UniProt: P20702

Pathways: Complement System, Activated T Cell Proliferation, Integrin Complex