NGFR antibody

Catalog No. ABIN318704

The Rabbit Polyclonal anti-NGFR antibody has been validated for WB and IF. It is suitable to detect NGFR in samples from Human and Mouse.

Quick Overview for NGFR antibody (ABIN318704)

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NGFR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-NGFR Antibody

Specificity: This antibody recognises CD271, a transmembrane protein of 70-75 kDa, otherwise known as Nerve Growth Factor Receptor (NGFR).

Purification: Purified

Immunogen: Recombinant human CD271

Isotype: IgG

Application Details

Application Notes: Western Blot: 1g/mL, detects a band of approximately 75-80 kDa in A-20 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: CD271 / NGFR

Background: CD 271 is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including AlzheimerSynonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16

Gene ID: 4804

NCBI Accession: NP_002498

UniProt: P08138

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding